abstract：:Several leukaemia-specific antigens have been discovered in the recent past, which raised the possibility for T-cell-based immunotherapy for leukaemia. However, failure of such approaches involving interleukin-2 and/or T-cell-based immunotherapy indicated the importance of investigation of the human leucocyte antigen ...

journal_title：Immunogenetics

authors： Majumder D,Bandyopadhyay D,Chandra S,Mukhopadhayay A,Mukherjee N,Bandyopadhyay SK,Banerjee S

更新日期：2005-09-01 00:00:00

abstract：:C3, C4, and C5 are thiolester-containing proteins (TEPs) of vertebrate complement. The identification of the molecular origin of the TEP family, and more specifically the ancestor protein of complement components C3, C4, and C5, remains a fundamental question. The prevailing paradigm suggests that duplication and dive...

journal_title：Immunogenetics

authors： Dishaw LJ,Smith SL,Bigger CH

更新日期：2005-08-01 00:00:00

abstract：:In the absence of suitable rodent animal models for Plasmodium falciparum malaria, the efficacy testing of asexual blood-stage vaccine candidates in Aotus nancymaae represents a tool to select between different formulations before conducting expensive human clinical trials. CpG oligonucleotides (ODN) specifically prom...

journal_title：Immunogenetics

authors： Spirig R,Peduzzi E,Patarroyo ME,Pluschke G,Daubenberger CA

更新日期：2005-05-01 00:00:00

abstract：:By determining the nucleotide sequences of more than 700 cDNA clones isolated from 16 cynomolgus monkeys, we identified 26 Mafa-B alleles. In addition, nine sequences with similarity to Mamu-I alleles were identified. Since multiple Mafa-B alleles were found in each individual, it was strongly suggested that the cynom...

journal_title：Immunogenetics

authors： Uda A,Tanabayashi K,Fujita O,Hotta A,Terao K,Yamada A

更新日期：2005-05-01 00:00:00

abstract：:In mammals many natural killer (NK) cell receptors, encoded by the leukocyte receptor complex (LRC), regulate the cytotoxic activity of NK cells and provide protection against virus-infected and tumor cells. To investigate the origin of the Ig-like domains encoded by the LRC genes, a subset of C2-type Ig-like domain s...

journal_title：Immunogenetics

authors： Nikolaidis N,Klein J,Nei M

更新日期：2005-04-01 00:00:00

abstract：:The collectin surfactant protein-D (SP-D) plays a significant role in innate immunity. Epidemiological studies described associations between single nucleotide polymorphisms (SNPs) of the human gene coding surfactant protein-D (SFTPD) and infectious pulmonary diseases. Studies on twins indicated very strong genetic de...

journal_title：Immunogenetics

authors： Heidinger K,König IR,Bohnert A,Kleinsteiber A,Hilgendorff A,Gortner L,Ziegler A,Chakraborty T,Bein G

更新日期：2005-04-01 00:00:00

abstract：:IgM and IgD genes of the Japanese flounder were cloned and characterized from a genomic bacterial artificial chromosome (BAC) library. The micro gene contained four constant region exons (Cmi1-Cmi4), and two transmembrane exons (miTM1 and miTM2), which conforms to the organizational pattern of all other vertebrate mic...

journal_title：Immunogenetics

authors： Srisapoome P,Ohira T,Hirono I,Aoki T

更新日期：2004-07-01 00:00:00

abstract：:In this study we have sequenced peptides eluted from a truncated recombinant HLA-A*6602 molecule, and compared their features with data reported for peptides presented in the A*6601 molecule. A striking change in the amino-acid binding preferences was observed at peptide position P1, which interacts with pocket A of t...

journal_title：Immunogenetics

authors： Bade-Doeding C,Elsner HA,Eiz-Vesper B,Seltsam A,Holtkamp U,Blasczyk R

更新日期：2004-05-01 00:00:00

abstract：:The vertebrate complement system is composed of about 30 serum and cell surface proteins that make up three activation pathways, a lytic pathway, and a set of proteins that regulate complement. Regulatory proteins are required for host protection against autologous complement attack and to control the amplification fe...

journal_title：Immunogenetics

authors： Multerer KA,Smith LC

更新日期：2004-05-01 00:00:00

abstract：:UV-inactivated GCHV (grass carp hemorrhage virus) is able to induce an antiviral state in cultured CAB cells (crucian carp Carassius auratus blastulae embryonic cells) via the production of interferon (IFN). In the current work, the full-length cDNAs of two Mx genes, termed CaMx1 and CaMx2, have been cloned and sequen...

journal_title：Immunogenetics

authors： Zhang YB,Li Q,Gui JF

更新日期：2004-04-01 00:00:00

abstract：:Apoptosis has been suggested as a major mechanism for the CD4(+) T-lymphocyte depletion observed in patients infected with human immunodeficiency virus 1 (HIV-1). To evaluate the impact of genetic variations to apoptosis during progression of acquired immunodeficiency syndrome (AIDS), we have performed an extensive ge...

journal_title：Immunogenetics

authors： Vasilescu A,Heath SC,Diop G,Do H,Hirtzig T,Hendel H,Bertin-Maghit S,Rappaport J,Therwath A,Lathrop GM,Matsuda F,Zagury JF

更新日期：2004-04-01 00:00:00

abstract：:We cloned the cDNAs and genes of two different types of toll-like receptors from Japanese flounder. The results of homology searches suggested that these genes (designated JF-TLR2 and JF-TLR22) are homologues of human TLR2 and fugu TLR22, respectively. The cDNAs of JF-TLR2 and JF-TLR22 encoded 818 and 961 amino acid r...

journal_title：Immunogenetics

authors： Hirono I,Takami M,Miyata M,Miyazaki T,Han HJ,Takano T,Endo M,Aoki T

更新日期：2004-04-01 00:00:00

abstract：:The rhesus macaque ( Macaca mulatta) has become a popular animal model for several human infectious diseases, such as HIV (modeled by SIV infection), hepatitis, and malaria. Investigation of T-cell responses in experimental infectious diseases in rhesus macaques has benefited from an expanding understanding of the div...

journal_title：Immunogenetics

authors： Su J,Luscher MA,MacDonald KS

更新日期：2004-03-01 00:00:00

abstract：:Genes of the major histocompatibility complex (MHC) have been characterized in all extant lineages of mammals. The tammar wallaby (Macropus eugenii) is well established as a model marsupial species; however, no classical MHC sequences have been described from this species. We have isolated two MHC class II beta-chain ...

journal_title：Immunogenetics

authors： Browning TL,Belov K,Miller RD,Eldridge MD

更新日期：2004-02-01 00:00:00

abstract：:The aim of this study was to evaluate the intra- and inter-population variability of the Gm/Km system in the Madonie Mountains, one of the main geographical barriers in north-central Sicily. We analysed 392 samples: 145 from Alia, 128 from Valledolmo, 25 from Cerda and 94 from Palermo. Serum samples were tested for G1...

journal_title：Immunogenetics

authors： Cerutti N,Dugoujon JM,Guitard E,Rabino Massa E

更新日期：2004-01-01 00:00:00

abstract：:The CCL4 chemokine is secreted by a variety of cells following stimulation. CCL4 affects several different types of cells that are important for acute inflammatory responses and are critical for the development of specific immune responses to foreign antigens. The human genome contains two genes for the CCL4 chemokine...

journal_title：Immunogenetics

authors： Lu J,Honczarenko M,Sloan SR

更新日期：2004-01-01 00:00:00

abstract：:In mammals, there are MHC class II molecules with distinctive sequence features, such as the classical isotypes DR, DQ and DP. These particular isotypes have not been reported in non-mammalian vertebrates. We have isolated the class II (B-L) alpha chain from outbred chickens as the basis for the cloning and sequencing...

journal_title：Immunogenetics

authors： Salomonsen J,Marston D,Avila D,Bumstead N,Johansson B,Juul-Madsen H,Olesen GD,Riegert P,Skjødt K,Vainio O,Wiles MV,Kaufman J

更新日期：2003-12-01 00:00:00

abstract：:MHC class II deficiency provokes a severe immunodeficiency characterized by a lack of antigen-specific immune response. In the absence of bone marrow transplantation (the only curative treatment), patients affected by this genetic recessive disease die in early childhood. However, others and we have recently described...

journal_title：Immunogenetics

authors： Prod'homme T,Dekel B,Barbieri G,Lisowska-Grospierre B,Katz R,Charron D,Alcaide-Loridan C,Pollack S

更新日期：2003-11-01 00:00:00

abstract：:Control of HIV-1 viremia and progression to AIDS has been associated with specific HLA genes. The tumor necrosis factor ( TNF) and the non-classical major histocompatibility (MHC) class I chain-related A ( MICA) genes are located in the genomic segment between the HLA class I and II genes and variants of both genes ha...

journal_title：Immunogenetics

authors： Delgado JC,Leung JY,Baena A,Clavijo OP,Vittinghoff E,Buchbinder S,Wolinsky S,Addo M,Walker BD,Yunis EJ,Goldfeld AE

更新日期：2003-10-01 00:00:00

abstract：:During parasitization of their hosts some insect parasitoids deliver resident viruses which encode genes that must be expressed in the host for successful parasitization. Among these viruses the Campoletis sonorensis Ichnovirus has been well studied and encodes a cys-motif gene family implicated in disruption of host ...

journal_title：Immunogenetics

authors： Dupas S,Turnbull MW,Webb BA

更新日期：2003-09-01 00:00:00

abstract：:We have isolated and characterized cDNAs and genes for pufferfish, Fugu rubripes, (Fugu) orthologues of mammalian interleukin (IL)-12 subunits (IL-12 p35 and IL-12 p40). The deduced amino acid sequences of the Fugu IL-12 subunits showed homology with mammalian IL-12 subunits (p35: 50.4-58.0% similarity; p40: 51.2-55.4...

journal_title：Immunogenetics

authors： Yoshiura Y,Kiryu I,Fujiwara A,Suetake H,Suzuki Y,Nakanishi T,Ototake M

更新日期：2003-08-01 00:00:00

abstract：:The rat major histocompatibility complex loci RT1-B and RT1-D are equivalent to the human leucocyte antigens HLA-DQ and HLA-DR respectively. Here we describe the complementary DNA (cDNA) sequence encoding the alpha and beta chains of both the RT1-B and RT1-D locus genes of the rat RT1u haplotype. We have found entire ...

journal_title：Immunogenetics

authors： Easterfield AJ,Bradley JA,Bolton EM

更新日期：2003-08-01 00:00:00

abstract：:Human IgG receptors (FcgammaR) display considerable heterogeneity, and are crucial immune response modulating molecules. FcgammaRIIA, FcgammaRIIIA, and FcgammaRIIIB display functional biallelic polymorphisms. FcgammaR polymorphisms have been found associated with susceptibility to infectious and autoimmune diseases. L...

journal_title：Immunogenetics

authors： van der Pol WL,Jansen MD,Sluiter WJ,van de Sluis B,Leppers-van de Straat FG,Kobayashi T,Westendorp RG,Huizinga TW,van de Winkel JG

更新日期：2003-07-01 00:00:00

abstract：:A large number of HLA-Cw4 (Cw *0402) peptides were purified, sequenced, and identified from breast and ovarian carcinoma cell lines. HLA-Cw4 molecules were expressed in these cells as soluble, secreted HLA (sHLA) and recovered from the growth medium. The peptides were separated by capillary reversed-phase HPLC and ana...

journal_title：Immunogenetics

authors： Buchsbaum S,Barnea E,Dassau L,Beer I,Milner E,Admon A

更新日期：2003-06-01 00:00:00

abstract：:Previous studies demonstrated that the diversity of the antibody response of mice to the inulin (In) determinant of bacterial levan is regulated by the gene Spectrotype Regulation 1 ( Sr1). BALB/c mice produce a monoclonal anti-In response as shown by isoelectric focusing analysis. In contrast, the anti-In antibody re...

journal_title：Immunogenetics

authors： Jones Tiffany L,Riblet R,Stein KE

更新日期：2003-05-01 00:00:00

abstract：:A cDNA clone, designated IL-8nL, was obtained by suppression subtractive hybridisation between lipopolysaccharide-stimulated and non-stimulated populations of the rainbow trout macrophage-like cell line, RTS11. IL-8nL was similar but not identical to a recently published sequence of the gene encoding rainbow trout int...

journal_title：Immunogenetics

authors： Fujiki K,Gauley J,Bols NC,Dixon B

更新日期：2003-05-01 00:00:00

abstract：:Chemokines are small, inducible, structurally related proteins that guide cells expressing the right chemokine receptors to sites of immune response. They have been identified and studied extensively in mammals, but little is known about their presence in other vertebrate groups. Here we describe seven new chemokines ...

journal_title：Immunogenetics

authors： Kuroda N,Uinuk-ool TS,Sato A,Samonte IE,Figueroa F,Mayer WE,Klein J

更新日期：2003-03-01 00:00:00

abstract：:Natural killer T (NKT) cells play an important role in controlling cancers, infectious diseases and autoimmune diseases. Although the rhesus macaque is a useful primate model for many human diseases such as infectious and autoimmune diseases, little is known about their NKT cells. We analyzed V alpha 24TCR+ T cells fr...

journal_title：Immunogenetics

authors： Kashiwase K,Kikuchi A,Ando Y,Nicol A,Porcelli SA,Tokunaga K,Omine M,Satake M,Juji T,Nieda M,Koezuka Y

更新日期：2003-02-01 00:00:00

abstract：:The genomic organisation of the major histocompatibility complex (MHC) seems to vary considerably between different bird species. In order to understand this variation it is important to gather information from different species. We have, for the first time, investigated MHC class II polymorphism in a wader species, t...

journal_title：Immunogenetics

authors： Ekblom R,Grahn M,Höglund J

更新日期：2003-01-01 00:00:00

abstract：:MICA and MICB genes encode MHC class I chain-related proteins, which are polymorphic, do not appear to present peptides or associate with beta(2)-microglobulin, and are expressed predominantly in epithelial cells, endothelial cells, fibroblasts and several cultured cell lines. Alternatively spliced isoforms are known ...

journal_title：Immunogenetics

authors： Zou Y,Stastny P

更新日期：2002-12-01 00:00:00

abstract：:A cDNA library screening using the conserved exon 4 of Atlantic salmon Mhc class I as probe provided the basis for a study on Mhc class I polymorphism in a breeding population. Twelve different alleles were identified in the 82 dams and sires studied. No individual expressed more than two alleles, which corresponded t...

journal_title：Immunogenetics

authors： Grimholt U,Drabløs F,Jørgensen SM,Høyheim B,Stet RJ

更新日期：2002-11-01 00:00:00

abstract：:CD4 has a central role in thymocyte differentiation and cell-mediated immunity. We isolated and analyzed chicken CD4. The gene spans 11.5 kb and is composed of ten exons. The promoter is TATA-less and similar to the mouse and human CD4 promoters, with two transcription start sites as determined by 5'RACE analysis. In ...

journal_title：Immunogenetics

authors： Koskinen R,Salomonsen J,Tregaskes CA,Young JR,Goodchild M,Bumstead N,Vainio O

更新日期：2002-10-01 00:00:00

abstract：:Human CS1, also known as novel Ly9, 19A24, or CRACC, is a member of the immunoglobulin gene superfamily (IgSF) expressed on natural killer cells and other leukocytes. Here we describe the cloning of the mouse homologue of this gene. The mouse novel Ly9 gene is shown to encode a transmembrane protein composed of two ex...

journal_title：Immunogenetics

authors： Tovar V,del Valle J,Zapater N,Martin M,Romero X,Pizcueta P,Bosch J,Terhorst C,Engel P

更新日期：2002-09-01 00:00:00

abstract：:Natural resistance-associated macrophage protein 1 (NRAMP1) has an important role in regulating macrophage functions that affect innate resistance as well as immune responses. We analyzed the microsatellite polymorphism in the promoter region of the human NRAMP1 gene in 206 type 1 diabetes patients and 200 normal chil...

journal_title：Immunogenetics

authors： Bassuny WM,Ihara K,Matsuura N,Ahmed S,Kohno H,Kuromaru R,Miyako K,Hara T

更新日期：2002-07-01 00:00:00

abstract：:The size of B-cell subsets appears to be under genetic control, but the mechanism of this regulation is unknown. By analyzing five congenic strains of mice that differ only in their H2 haplotype, we addressed the issue of whether the MHC genes are involved in the relative proportions of B-1a, B-1b and B-2 cells. Not o...

journal_title：Immunogenetics

authors： Pers JO,Jamin C,Lydyard PM,Charreire J,Youinou P

更新日期：2002-06-01 00:00:00

abstract：:A strong correlation between the TT(-889) genotype over CC(-889) of the interleukin-1 alpha (IL-1 alpha) transcription regulatory region and age of Alzheimer's disease onset has recently been reported. To determine the functional effects of the genetic variants on plasma protein levels, we cloned the promoter region a...

journal_title：Immunogenetics

authors： Dominici R,Cattaneo M,Malferrari G,Archi D,Mariani C,Grimaldi LM,Biunno I

更新日期：2002-05-01 00:00:00

abstract：:The emergence in Camelidae species of functional antibodies devoid of light chains (referred to as heavy-chain antibodies or HCAbs) is an intriguing evolutionary event. Homodimeric HCAbs have also been documented in spotted ratfish ( Cos5-Abs) and nurse shark (NAR). To reveal the evolutionary history of HCAbs, we eval...

journal_title：Immunogenetics

authors： Nguyen VK,Su C,Muyldermans S,van der Loo W

更新日期：2002-04-01 00:00:00

abstract：:Six IgA allotypes are serologically identifiable in inbred mice. The sequences of the PCR-amplified C alpha 1, C alpha 2 and C alpha 3 exons from the genomic DNA of mice of four previously unsequenced allotypes already have been compared with those of BALB/c and of a wild mouse, Mus pahari, in the literature. Sporadic...

journal_title：Immunogenetics

authors： Phillips-Quagliata JM

更新日期：2002-03-01 00:00:00

abstract：:We selected 38 consecutive celiac disease (CD) patients (from a group of 316 consecutive CD patients) and 91 healthy blood donors, all of whom were HLA-DQ2 (DQA1*0501/DQB1*0201) negative, and investigated the presence of the classically associated alleles HLA-DQ8 and HLA-DRB4. We also studied the distribution of MICA ...

journal_title：Immunogenetics

authors： Lopez-Vazquez A,Rodrigo L,Fuentes D,Riestra S,Bousoño C,Garcia-Fernandez S,Martinez-Borra J,Gonzalez S,Lopez-Larrea C

更新日期：2002-02-01 00:00:00

abstract：:We have studied the MICA alleles of 196 unrelated subjects from three South American Indian tribes (Toba, Wichi and Terena). They are members of isolated tribes located in the Gran Chaco area in northeastern Argentina and in Mato Grosso do Sul in South Central Brazil. Of 55 previously known alleles, nine were observed...

journal_title：Immunogenetics

authors： Zhang Y,Lazaro AM,Zou Y,Lavingia B,Moraes EM,Moraes RJ,Stastny P

更新日期：2002-02-01 00:00:00